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KMID : 0367219950120020151
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Sejong Medical Journal
1995 Volume.12 No. 2 p.151 ~ p.162
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The Effects of Lipo PGE1 in Patients with Ductus Dependent Congenital Heart Disease
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손세정
강미정/이상엽/김성호/배은정/박인승
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Abstract
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The adverse reactions of PGE1 are troublesome in the preoperative management of critical patients with ductus dependent congenital heart disease, and a preparation with less adverse reactions is preferable. The effects of Lipo PGE1 a new
preparation of
PGE1 contained in lipid microspheres, were compared with those of conventional PGE1(PGE1-CD). Lipo PGE1 was infused at a rate of 5ng/㎏/min in 9 patients, PGE1-CD at a rate between 10 and 50ng/㎏/min in 13 patients. Clinically, both treatment
were
effective in relieving cyanosis and hypoxemia except in patients already having either a closes ductus or a severe hypoxemia and acidosis. The increments of PaO2 one hour after infusion were 9.9 and 5.4 mmHg, respectively and even though there
was
no
significant difference a clinical response rate(88.9% vs 69.2%), the mean dose of Lipd PGE1 at appearance of responses was about 10 times less than that of PGE1-CD in overall patients and 6.5 times in patients with ductus dependent pulmonary
circulation. The adverse reactions occurred in 55.6% of the patients given Lipo PGE1, while it was 84.6% in those administered PGE1-CD. The severity of the adverse reactions in Lipo PGE1 groups was much milder than that in PGE1-CD group. As the
incidence of the adverse reactions increased at dose over 5 ng/㎏/min, the initial dose of 5 ng/㎏/min seemed to be appropriate for Lipo PGE1. In conclusion, Lipo PGE1 was effective at a lower dose than was PGE1-CD, and was associated with fewer
or
less
severe adverse reactions, and is therefore judged to be more suitable for clinical use than conventional PGE1-CD.
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KEYWORD
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